We unleash your business potential by maximize the business innovation.
Send EmailSalcaprozate Sodium, SNAC, 203787-91-1
🧪 Technical Specifications
| Property | Description |
|---|---|
| Chemical Name | Salcaprozate Sodium |
| CAS Number | 203787-91-1 |
| Molecular Formula | C₁₅H₂₀NNaO₄ |
| Molecular Weight | 303.33 g/mol |
| Appearance | White to off-white crystalline powder |
| Melting Point | 183–185 °C |
| Solubility | ~33 mg/mL in water; slightly soluble in DMSO and methanol |
| Stability | Hygroscopic; store in sealed containers |
| Storage Conditions | Room temperature, dry and airtight |
💊 Applications
SNAC is primarily used as an oral absorption enhancer for drugs that are poorly absorbed through the gastrointestinal tract:
-
Peptide and protein-based drugs (e.g., insulin, heparin, vitamin B12)
-
GLP-1 agonists like oral semaglutide for type 2 diabetes
-
Pharmaceutical formulations as an excipient
-
Medical foods (recognized as GRAS by the FDA)
✅ Suitability Table
| Use Case | Formulation Type | Suitability |
|---|---|---|
| Oral peptide delivery | Tablet / capsule | ✅ High |
| Injection alternative | Oral formulation | ✅ High |
| Vitamin B12 enhancement | Oral solution/tablet | ✅ Moderate |
| Medical food additive | Powder / liquid | ✅ Safe |
| General excipient use | Pharmaceutical base | ✅ Industrial |
🧪 Synonyms and Alternate Names
-
SNAC (abbreviation)
-
Salcaprozate Sodium
-
Sodium 8-(2-hydroxybenzamido)octanoate
-
Octanoic acid, 8-[(2-hydroxybenzoyl)amino]-, monosodium salt
-
Sometimes referenced under excipient codes or internal formulation IDs
📌 Usage Recommendations
-
Dosage: Depends on the active ingredient; typically used in milligram quantities
-
Formulation: Incorporated into tablets or capsules alongside the active drug
-
Combination: May be paired with protease inhibitors to enhance effect
⚠️ Precautions
-
High doses (e.g., 2000 mg/kg/day) in animal studies showed some adverse effects, though not conclusively linked to SNAC
-
Hygroscopic nature: Must be protected from moisture
-
Gastrointestinal sensitivity: Rare cases of mild stomach discomfort or electrolyte imbalance
-
Drug interactions: Should be evaluated when used with other permeation enhancers
SNAC is a transformative excipient in pharmaceutical science, enabling oral delivery of biologics that were previously injectable-only.
